Journal
ANALYTICAL CHEMISTRY
Volume 88, Issue 6, Pages 2989-2993Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b04661
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC) Innovative Green Wood Fibre Products Network
- NSERC Discovery Grant
- Canada Foundation for Innovation
- British Columbia Knowledge Development Fund
- UBC faculty funding
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Cellulose has emerged as an attractive substrate for the production of economical, disposable, point-of-care (POC) analytical devices. Development of novel methods of (bio)activation is central to broadening the application space of cellulosic materials. Ironically, such efforts are stymied, by the inherent biocompatibility and recalcitrance of cellulose fibers. Here, we have elaborated a versatile, chemo-enzymatic approach to activate cellulosic materials for CuAAC click chemistry, to develop new fluorogenic esterase sensors. Gentle, aqueous modification conditions facilitate broad applicability to cellulose papers, gauzes, and hydrogels. Tethering of the released fluorophord to the cellulose surface prevents signal degradation due to diffusion and enables straightforward, sensitive visualization with a simple light source in resource limited situations.
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