Journal
ANALYTICAL CHEMISTRY
Volume 88, Issue 3, Pages 1530-1534Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b04863
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Funding
- National Natural Science Foundation of China [21375098]
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We report the first portable upconversion nanoparticles (UCNPs)-based paper device for road-side field testing of cocaine. Upon the recognition of cocaine by two pieces of rationally designed aptamer fragments, the luminescence of UCNPs immobilized on the paper is quenched by Au nanoparticles (AuNPs), which indicates the cocaine concentration. This device can give quantitative results in a short time with high sensitivity using only a smartphone as the apparatus. Moreover, this device is applicable in human saliva samples, and it also can be used to monitor the cocaine content change in blood samples. The results of this work demonstrate the prospect of developing UCNPs-based paper devices for field testing of drug abuse.
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