Journal
OBESITY
Volume 27, Issue 4, Pages 535-541Publisher
WILEY
DOI: 10.1002/oby.22413
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Funding
- National Institutes of Health [DK94416, DK56341, DK092950, DK20579, RR024992]
- National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [U01 DK094418, U01 DK094463, U01 DK094416, 5U01 DK094466]
- National Heart, Lung, and Blood Institute (NHLBI) [U01 HL114344, U01 HL114377]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [U01 HD072834]
- National Center for Complementary and Integrative Health (NCCIH)
- NIH Office of Research on Women's Health (ORWH)
- Office of Behavioral and Social Sciences Research (OBSSR)
- Indian Health Service
- Intramural Research Program of the NIDDK
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Objective This study aimed to assess the efficacy of a home-based lifestyle intervention delivered through Parents as Teachers (PAT), a national home-visiting organization, designed to minimize excessive weight gain through 12 months post partum in socioeconomically disadvantaged (SED) African American women with overweight or obesity. Methods This randomized controlled trial was conducted at a single center as part of the Lifestyle Interventions for Expectant Moms (LIFE-Moms) consortium. Analysis was conducted with 185 SED African American women (BMI 25.0-45.0 kg/m(2) at pregnancy onset) retained from an original sample of 267 randomized to standard PAT or PAT+Lifestyle, which embedded lifestyle therapy within standard PAT delivered prenatally and for 12 months post partum. Results Compared with standard PAT, the PAT+Lifestyle group gained less weight (2.5 kg vs. 5.7 kg; P = 0.01) and were more likely to return to their baseline weight (38.0% vs. 21.5%; P = 0.01) from baseline to 12 months post partum. There were no differences between groups in cardiometabolic outcomes, indices of glycemic control and insulin sensitivity, and plasma lipid profile. The estimated cost of PAT+Lifestyle was $81 more to deliver per family than standard PAT. Conclusions PAT+Lifestyle decreases weight gain during pregnancy through 12 months post partum in SED African American women with overweight or obesity at the start of pregnancy with minimal additional cost.
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