Journal
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
Volume 71, Issue 2, Pages 214-222Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/01635581.2019.1578394
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- Natural Science Foundation of Sichuan Science and Technology Agency [2018JY0167]
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Aim: Few evidences are available regarding the link between microbiota composition in the human colorectal cancer (CRC) tissues and the patients' clinicopathological features. Methods: Microbiota diversity in CRC tissues (n = 30) were profiled and compared by high-throughput sequencing with clinicopathological features, including tumor location, differentiation degree, metastasis, and CRC patients' gender and age. Results: Many bacteria with significant difference in abundance were identified associated with these clinicopathological features (P < 0.05). There was a significant difference in microbial composition between right colon cancers (RCa) vs. left colon cancers (LCa), RCa vs. rectal cancers (P < 0.05). The amount of Fusobacteria was significantly higher in LCa, moderately and poorly differentiated cancers (MPD), and young patients (<60 years), compared to RCa, well differentiated cancers (WD) and elder patients (>60 years), respectively (P < 0.05). Helicobacter spp. in RCa and MPD patients was significantly higher than in LCa and WD patients (P < 0.05). Firmicutes in non-lymph node metastasis (LNM) patients was significantly lower than in LNM patients (P < 0.05). Conclusion: The different microbiota composition in the CRCs was associated with patients' clinicopathological features, which could be a consequence of microflora diversity.
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