Journal
ANALYTICAL CHEMISTRY
Volume 88, Issue 14, Pages 7206-7212Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b01391
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Funding
- NSFC [21431002]
- Fundamental Research Funds for the Central Universities [lzujbky-2015-k04]
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Hydrogen polysulfide (H2Sn) has attracted increasing attention due to the fact that it is actually the key signaling molecule rather than hydrogen sulfide (H2Sn). Therefore, developing a sensitive and accurate assay to investigate the biosynthetic pathways of H2Sn is of physiological and pathological significance. In this work, based on the commonly used two-photon fluorophore, 1,8-naphthalimide, a new probe, NRT-HP, has been designed and synthesized that displayed both one- and two-photon ratiometric fluorescence changes toward H2Sn via H2Sn-mediated benzodithiolone formation. NRT-HP exhibits excellent pH stability, high selectivity and low detection limit (0.1 mu M) in aqueous media. Furthermore, two-photon fluorescence microscopy experiments have demonstrated that NRT-HP could be used for the H2Sn detection in live cells as well as tissue slices.
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