Journal
ANALYTICAL CHEMISTRY
Volume 88, Issue 22, Pages 11253-11260Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b04087
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Funding
- National Natural Science Foundation of China [NSFC 21572177, 21272184, 21103137, J1210057]
- Shaanxi Provincial Natural Science Fund Project [2015JZ003, 2016JZ004]
- Xi'an City Science and Technology Project [CXY1511(3)]
- Northwest University Science Foundation for Postgraduate Students [YZZ14052, YZZ15040, YZZ15045, YZZ15006]
- DFG [OB 362/1-1]
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A broad-spectrum fluorescent probe, which can be applied to monitoring H2S in various biological systems, has been rationally designed and synthesized. This specific probe was applied to localize the endogenous H2S in living Raw264.7 macrophage cells, HepG2 cells, and H9C2 cells. At the same time, the probe has successfully visualized CBS- and CSE-induced endogenous H2S production and monitored CBS and CSE activity in H9C2 cells. This probe could serve as a powerful molecular imaging tool to further explore the physiological function and the molecular mechanisms of endogenous H2S in living animal systems.
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