Journal
NEURON
Volume 101, Issue 4, Pages 615-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2018.12.023
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Funding
- DFG [TRR128, CIPSM EXC114, CRC870, Mi 694/8-1, Ke 774/5-1/Mi694/7-1]
- European Research Council (ERC, FP/2007-2013) [310932]
- BMBF (KKNMS)
- DMSG
- Verein Therapieforschung fur MS-Kranke e.V.
- ERC [616791]
- Munich Cluster for Systems Neurology (SyNergy) [EXC 1010]
- Graduate School of the TU Munchen
- FoFoLe'' program at LMU Munich
- Wings for Life'' foundation
- European Research Council (ERC) [616791, 310932] Funding Source: European Research Council (ERC)
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Axon loss determines persistent disability in multiple sclerosis patients. Here, we use in vivo calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels determine the choice between axon loss and survival. We rule out the endoplasmic reticulum, glutamate excitotoxicity, and the reversal of the sodium-calcium exchanger as sources of intra-axonal calcium accumulation and instead identify nanoscale ruptures of the axonal plasma membrane as the critical path of calcium entry.
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