Pediatric high grade gliomas: Clinico-pathological profile, therapeutic approaches and factors affecting overall survival

Introduction. - Pediatric high grade gliomas are rare tumors of the central nervous system. Treatment is multidisciplinary, comprising surgical excision followed by radiotherapy and/or chemotherapy. Objectives. - describe these tumors' characteristics as seen in our institution, and identify factors associated with better overall survival. Patients and methods. - We conducted a retrospective study of 30 cases of pediatric high grade glioma treated consecutively in our institution over a 20-year period. Brainstem tumors and patients aged more than 22 years were excluded. Univariate analysis was conducted to determine factors associated with better overall survival. Results. - The series comprised 30 pediatric high grade gliomas: 27 glioblastomas and 3 anaplastic astrocytomas. The sex ratio was 1.7. Mean age was 13 years. Tumors were mainly located in the cerebral hemispheres (63.3%). Median tumor size was 5 cm. Glioblastomas were subdivided into 26 cases of classical subtype (96.3%) and 1 case of epithelioid subtype (3.7%). Surgical strategy consisted in tumor resection in 24 cases (80%). Twenty-one patients (70%) received postoperative radiotherapy. Therapeutic response at end of treatment was complete in 7 cases (23.3%). Postoperative radiation therapy and complete treatment response were significantly associated with improved overall survival in all high grade gliomas and also specifically in glioblastomas (P < 0.001 and P = 0.005, respectively). Conclusion. - Our results suggest that postoperative radiotherapy and complete treatment response are predictive factors for better overall survival in pediatric high grade glioma. (C) 2019 Elsevier Masson SAS. All rights reserved.