Journal
NEURO-ONCOLOGY
Volume 21, Issue 4, Pages 537-546Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/noy202
Keywords
gene therapy; glioblastoma; immunotherapy; immuno-oncology; viral therapy
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Funding
- Matthew Larson Foundation
- Credit Unions Kids at Heart Program
- Joe Andruzzi Foundation
- CJ Buckley Brain Cancer Research Fund
- Stop and Shop Pediatric Brain Tumor Program
- Zach Carson Fund
- Ellie Kavalieros DIPG Fund
- Advantagene, Inc.
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Background Gene-mediated cytotoxic immunotherapy (GMCI) is a tumor-specific immune stimulatory strategy implemented through local delivery of aglatimagene besadenovec (AdV-tk) followed by anti-herpetic prodrug. GMCI induces T-cell dependent tumor immunity and synergizes with radiotherapy. Clinical trials in adult malignant gliomas demonstrated safety and potential efficacy. This is the first trial of GMCI in pediatric brain tumors. Methods This phase I dose escalation study was conducted to evaluate GMCI in patients 3 years of age or older with malignant glioma or recurrent ependymoma. AdV-tk at doses of 1 x 10(11) and 3 x 10(11) vector particles (vp) was injected into the tumor bed at the time of surgery followed by 14 days of valacyclovir. Radiation started within 8 days of surgery, and if indicated, chemotherapy began after completion of valacyclovir. Results Eight patients (6 glioblastoma, 1 anaplastic astrocytoma, 1 recurrent ependymoma) were enrolled and completed therapy: 3 on dose level 1 and 5 on dose level 2. Median age was 12.5 years (range 7-17) and Lansky/Karnofsky performance scores were 60-100. Five patients had multifocal/extensive tumors that could not be resected completely and 3 had gross total resection. There were no dose-limiting toxicities. The most common possibly GMCI-related adverse events included Common Terminology Criteria for Adverse Events grade 1-2 fever, fatigue, and nausea/vomiting. Three patients, in dose level 2, lived more than 24 months, with 2 alive without progression 37.3 and 47.7 months after AdV-tk injection. Conclusions GMCI can be safely combined with radiation therapy with or without temozolomide in pediatric patients with brain tumors and the present results strongly support further investigation. Clinical trial registry ClinicalTrials.gov NCT00634231
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