Journal
NATURE REVIEWS GENETICS
Volume 20, Issue 6, Pages 341-355Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41576-019-0113-7
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Funding
- NHLBI NIH HHS [R01 HL105704] Funding Source: Medline
- NIAID NIH HHS [R33 AI120977] Funding Source: Medline
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Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly moving from research to clinical laboratories. This emerging approach is changing how physicians diagnose and treat infectious disease, with applications spanning a wide range of areas, including antimicrobial resistance, the microbiome, human host gene expression (transcriptomics) and oncology. Here, we focus on the challenges of implementing mNGS in the clinical laboratory and address potential solutions for maximizing its impact on patient care and public health.
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