Journal
NATURE GENETICS
Volume 51, Issue 3, Pages 470-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41588-018-0336-0
Keywords
-
Categories
Funding
- Tailor-Made Medical Treatment program (the BioBank Japan Project) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Japan Agency for Medical Research and Development (AMED)
- MEXT KAKENHI [221S0002]
- Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University
- Japan Society for the Promotion of Science (JSPS) KAKENHI [15H05670, 15H05911, 15K14429]
- AMED [18gm6010001h0003, 18ek0410041h0002]
- Takeda Science Foundation
- Uehara Memorial Foundation
- Naito Foundation
- Daiichi Sankyo Foundation of Life Science
- Senri Life Science Foundation
- Suzuken Memorial Foundation
- JSPS KAKENHI [P16H06502]
- Bioinformatics Initiative of Osaka University Graduate School of Medicine
Ask authors/readers for more resources
To perform detailed fine-mapping of the major-histocompatibility-complex region, we conducted next-generation sequencing (NGS)-based typing of the 33 human leukocyte antigen (HLA) genes in 1,120 individuals of Japanese ancestry, providing a high-resolution allele catalog and linkage-disequilibrium structure of both classical and nonclassical HLA genes. Together with population-specific deep-whole-genome-sequencing data (n = 1,276), we conducted NGS-based HLA, single-nucleotide-variant and indel imputation of large-scale genome-wide-association-study data from 166,190 Japanese individuals. A phenome-wide association study assessing 106 clinical phenotypes identified abundant, significant genotype-phenotype associations across 52 phenotypes. Fine-mapping highlighted multiple association patterns conferring independent risks from classical HLA genes. Region-wide heritability estimates and genetic-correlation network analysis elucidated the polygenic architecture shared across the phenotypes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available