Journal
ANALYTICAL CHEMISTRY
Volume 88, Issue 18, Pages 8926-8930Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.6b02732
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Funding
- U.S. Department of Energy (DOE), Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences and Biosciences
- DOE [DE-AC02-07CH11358]
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Nanoparticles (NPs) have been suggested as efficient matrixes for small molecule profiling and imaging by laser-desorption ionization mass spectrometry (LDI-MS), but: so far there has been no systematic study comparing different NPs the analysis of various classes of small molecules. Here, we present a large scale screening of 13 NPs for the analysis of twin dozen small metabolite molecules. Many NPs showed Much higher LDI efficiency than organic matrixes in positive mode and some NPs showed comparable efficiencies for selected analytes in negative mode. Our results suggest that a thermally driven desorption process is a key factor for metal oxide NPs, but chemical interactions are also very important, especially for other NPs. The screening results provide a useful guideline for the selection of NPs in the LDI-MS analysis of small molecules.
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