Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 4, Pages 633-636Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1582046
Keywords
Apocynaceae; Nerium oleander; hot extract; cold extract; poliovirus; antiviral activity
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The study found that extracts from Nerium oleander have antiviral activity against polio virus type 1, with the mechanism of action identified to be within the first two hours post infection.
Nerium oleander (NO), a member of the Apocynaceae family, is an ornamental plant. In this study, we evaluated the antiviral activity of hot and cold extract of NO against six different viruses such as herpes simplex virus type 1 (HSV-1), polio virus type 1 (Sb-1), vesicular stomatitis virus (VSV), reovirus type-1 (Reo-1), human immunodeficiency virus type-1 (HIV-1), and yellow fever virus (YFV). Interestingly the results of plaque reduction assay demonstrated that both, hot extract and cold extract (breastin) of NO inhibited Sb-1 viral infection. In order to identify the mechanism by which NO exerts its antiviral activity, the virucidal effect, the time of addition and the adsorption assay were carried out. Results demonstrated that NO exerts its effect after infection period, particularly during the first two hours post infection.
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