Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 4, Pages 548-555Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1585845
Keywords
Asterosaponin; starfish; Acanthaster planci; cytotoxicity; clonogenic assay
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Funding
- RFBR (Russian Foundation for Basic Research) [18-53-54002 Viet_a]
- FEB RAS (Far East Branch of the Russian Academy of Sciences) [VAST 18-003]
- Grant of Viet Nam Academy of Science and Technology [QTRU02.03/18-19]
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A new asterosaponin, acanthaglycoside G, was isolated from the starfish Acanthaster planci collected off the coast of Vietnam, along with three known steroidal oligoglycosides. Compounds 3 and 4 showed cytotoxic activities against certain cancer cell lines, while compounds 1 and 2 were less active or inactive. The structure of compound 1 was elucidated using NMR and ESIMS techniques.
New asterosaponin, acanthaglycoside G (1), along with three previously known steroidal oligoglycosides (2-4), were isolated from the ethanolic extract of the starfish Acanthaster planci, collected off the coast of Vietnam. The structure of 1 was mainly elucidated by extensive NMR and ESIMS techniques as sodium 6-O-{beta-D-fucopyranosyl-(1 -> 2)-beta-D-quinovopyranosyl-(1 -> 4)-[beta-D-quinovopyranosyl-(1 -> 2)]-beta-D-quinovopyranosyl-(1 -> 3)-beta-D-quinovopyranosyl}-6 alpha-hydroxy-5 alpha-pregn-9(11)-en-20-one-3 beta-yl sulfate. Compounds 3 and 4 showed slight cytotoxic activities against cancer RPMI-7951, HT-29, and MDA-MB-231 cell lines, but effectively inhibited in non-toxic concentrations colony formation of HT-29 and MDA-MB-231 cells and cell migration of MDA-MB-231 cells. Compounds 1 and 2 were inactive or less active, respectively. [GRAPHICS] .
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