Neo-debromoaplysiatoxin C, with new structural rearrangement, derived from debromoaplysiatoxin

Neo-debromoaplysiatoxin C (1), a new member of the aplysiatoxin family, was isolated from the marine cyanobacteriumLyngbyasp. The structure of1was elucidated based on spectroscopic data, and its stereochemistry was determined from NOESY spectrum and biosynthetic considerations. This new compound presents an intriguing 10-membered lactone ring skeleton derived from debromoaplysiatoxin by structural rearrangement, which is the first example in the aplysiatoxin family. Its biological properties were evaluated for cytotoxicity, PKC delta activation and inhibitory effects on potassium channel.