Journal
NANOSCALE RESEARCH LETTERS
Volume 14, Issue -, Pages -Publisher
SPRINGER
DOI: 10.1186/s11671-019-2941-y
Keywords
Toxicity; Nanoparticles; Cytoskeleton rearrangements; Biomechanics; Young's Modulus
Funding
- action POR Puglia FESR-FSE 2014-2020 - Asse prioritario 1 - Ricerca, sviluppo tecnologico, innovazione - Azione 1.6 Interventi per il rafforzamento del sistema innovativo regionale e nazionale e incremento della collaborazione tra imprese e strutture di
- Marie Sklodowska-Curie Actions
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The nowadays growing use of nanoparticles (NPs) in commercial products does not match a comprehensive understanding of their potential harmfulness. More in vitro investigations are required to address how the physicochemical properties of NPs guide their engulfment within cells and their intracellular trafficking, fate, and toxicity. These nano-bio interactions have not been extensively addressed yet, especially from a mechanical viewpoint. Cell mechanic is a critical indicator of cell health because it regulates processes like cell migration, tissue integrity, and differentiation via cytoskeleton rearrangements. Here, we investigated in vitro the elasticity perturbation of Caco-2 and A549 cell lines, in terms of Young's modulus modification induced by SiO2NPS and TiO2NPS. TiO(2)NPs demonstrated stronger effects on cell elasticity compared to SiO(2)NPs, as they induced significant morphological and morphometric changes in actin network. TiO2NPS increased the elasticity in Caco-2 cells, while opposite effects have been observed on A549 cells. These results demonstrate the existence of a correlation between the alteration of cell elasticity and NPs toxicity that depends, in turn, on the NPs physicochemical properties and the specific cell tested.
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