Journal
NANOMEDICINE
Volume 14, Issue 5, Pages 529-552Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2018-0450
Keywords
alpha-eleostearic acid; flow cytometry; inflammation; molecular docking; nanoemulsion
Funding
- Indian Council of Medical Research (ICMR)-SRF fund [3/1/2/40/2014-15]
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The present work provides first-time empirical and molecular interaction evidence to establish the higher biofunctionality of a therapeutic lipid, alpha-eleostearic acid (ESA), encapsulated in a novel and thoroughly characterized biocompatible nanoemulsion (NE) system (particle size < 200 nm). Materials & methods: A novel methodology was employed to fabricate novel formulations of ESA. Molecular biological tools and assays were used to arrive at definite conclusions. Results: The proinflammatory profile was found to be significantly mitigated in the hypersensitized rats administered with the ESA-NE formulation more emphatically as compared with ESA-conventional emulsion in both in vivo and ex vivo models. Conclusion: The novel ESA-NE formulation shows a lot of palpable promise for clinical applications. [GRAPHICS]
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