Journal
MOLECULES
Volume 24, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/molecules24030614
Keywords
thiosemicarbazides; anti-Toxoplasma gondii activity; toxicity; SAR analysis
Funding
- Medical University of Lublin [DS 15]
- Faculty of Biology and Environmental Protection, University of Lodz [B1711000000263.01]
Ask authors/readers for more resources
One of the key stages in the development of new therapies in the treatment of toxoplasmosis is the identification of new non-toxic small molecules with high specificity to Toxoplasma gondii. In the search for such structures, thiosemicarbazide-based compounds have emerged as a novel and promising leads. Here, a series of imidazole-thiosemicarbazides with suitable properties for CNS penetration was evaluated to determine the structural requirements needed for potent anti-Toxoplasma gondii activity. The best 4-arylthiosemicarbazides 3 and 4 showed much higher potency when compared to sulfadiazine at concentrations that are non-toxic to the host cells, indicating a high selectivity of their anti-toxoplasma activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available