Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 63, Issue 8, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.201800930
Keywords
Akkermansia spp; flavonoids; gut-liver axis; gut microbiota transplantation; non-alcoholic fatty liver disease
Categories
Funding
- Fondo Europeo de Desarrollo Regional (FEDER) [BFU2013-48141-R, BFU2017-87960-R]
- Junta de Castilla y Leon [LE135U13, GRS 1428/A/16]
- FEDER [LE063U16]
- IIS Hospital La Fe [2017 0092 PP]
- Junta de Castilla y Leon - European Social Fund
- Fundacion de Investigacion Sanitaria of Leon
- CIBERehd contracts
- Instituto de Salud Carlos III, Spain
- Ministerio de Economia y Competitividad
Ask authors/readers for more resources
Scope Modulation of intestinal microbiota has emerged as a new therapeutic approach for non-alcoholic fatty liver disease (NAFLD). Herein, it is addressed whether gut microbiota modulation by quercetin and intestinal microbiota transplantation can influence NAFLD development. Methods and results Gut microbiota donor mice are selected according to their response to high-fat diet (HFD) and quercetin in terms of obesity and NAFLD-related biomarkers. Germ-free recipients displayed metabolic phenotypic differences derived from interactions between microbiota transplanted, diets, and quercetin. Based on the evaluation of hallmark characteristics of NAFLD, it is found that gut microbiota transplantation from the HFD-non-responder donor and the HFD-fed donor with the highest response to quercetin results in a protective phenotype against HFD-induced NAFLD, in a mechanism that involves gut-liver axis alteration blockage in these receivers. Gut microbiota from the HFD-responder donor predisposed transplanted germ-free mice to NAFLD. Divergent protective and deleterious metabolic phenotypes exhibited are related to definite microbial profiles in recipients, highlighting the predominant role of Akkermansia genus in the protection from obesity-associated NAFLD development. Conclusions The results provide scientific support for the prebiotic capacity of quercetin and the transfer of established metabolic profiles through gut microbiota transplantation as a protective strategy against the development of obesity-related NAFLD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available