Journal
MOLECULAR IMMUNOLOGY
Volume 106, Issue -, Pages 69-76Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2018.12.021
Keywords
The peptidoglycan recognition proteins; Innate immune; Toll, IMD and PPO pathway; Antimicrobial peptides
Categories
Funding
- China Postdoctoral Science Special Foundation [2017M5654]
- National Natural Science Foundation of China [81502621, 81502088, 31872425]
- Postdoctoral Science Foundation of China [2015M571678]
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Insects lack an acquired immune system and rely solely on the innate immune system to combat microbial infection. The innate immunity of insects mainly depends on the interaction between the host's pattern recognition receptor (PRR) and pathogen-associated molecular pattern (PAMP). The peptidoglycan recognition proteins (PGRPs) family is the most important pattern recognition receptor (PRR) for insects. It can recognize the main component of the cell wall of the pathogenic microorganism, peptidoglycan (PGN), and plays an important role in the innate immunity of insects. In this paper, the structure, classification, and function of PGRPs is summarized, and the role of PGRPs in the innate immunity of insects is also discussed.
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