Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 482, Issue -, Pages 18-27Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2018.12.003
Keywords
Adipose tissue; Fructose; Browning; Uncoupling protein-1; Thermogenesis
Categories
Funding
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [302.920/2016-1]
- FAPERJ (Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Rio de Janeiro) [E-26/202.935/2017]
- CNPq [305865/2017-0, 401001/2016-4]
- FAPERJ [E-26/202.795/2017, E-26/201.683/2017]
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The role of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in browning and thermogenesis has not been fully elucidated. Thus, we meant to evaluate the effect of EPA and DHA, administered alone or combined, with the activation of browning markers in subcutaneous white adipose tissue (sWAT), and thermogenic markers in brown adipose tissue (BAT). C57BL/6 adult male mice received a control diet or a high-fructose diet (HFru) for eight weeks, but after the first three weeks, HFru was divided into new groups: HFru, HFru + EPA, HFru + DHA, and HFru-EPA + DHA. EPA and DHA diminished adipocyte hypertrophy, recovered markers of browning in sWAT and thermogenic factors in the BAT, and improved gene expressions linked with mitochondrial biogenesis and lipid metabolism. Importantly, EPA and DHA administrated alone showed stronger results than the combination of EPA + DHA. The results suggest that EPA and DHA might be useful as adjuvant strategies to treat metabolic-associated disorders.
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