Journal
MICROCHIMICA ACTA
Volume 186, Issue 3, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-019-3304-1
Keywords
Cotton carbon fiber; Silver nanoparticles; Superoxide anion; Electrochemical sensor; Antioxidant; Oxidative stress; Cancer cell
Categories
Funding
- National Natural Science Foundation of China [21565021]
- Program for Chang Jiang Scholars and Innovative Research Team, Ministry of Education, China [IRT1283]
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A sensor is described for determination of superoxide anion (O-2(-)). The electrode consists of nitrogen-doped cotton carbon fiber (NCFs) modified with silver nanoparticles (AgNPs) which have excellent catalytic capability. The resulting sensor, best operated at working potentials around -0.5V (vs. SCE), can detect O-2(-) over an extraordinarily wide range that covers 10 orders of magnitude, and the detection limit is 2.320.07 fM. The electrode enables the release of O-2(-) from living cells under normal or under oxidative stress conditions to be determined. The ability to scavenge the superoxide anions of antioxidants was also investigated. In the authors' perception, the method represents a viable tool for studying diseases related to oxidative stress.
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