Journal
MICROCHIMICA ACTA
Volume 186, Issue 4, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-019-3318-8
Keywords
CEC; Magnetic nanoparticles; Open-tubular capillary; Enantiomeric separation; Dns-amino acids; Magnetic coationg; Ionic liquid
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Funding
- Natural Science Foundation of Jiangsu Province [BK20141353]
- Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Magnetic nanoparticles (MNPs) modified with -cyclodextrin and mono-6-deoxy-6-(1-methylimidazolium)--cyclodextrin tosylate (an ionic liquid), which called MNP--CD and MNP--CD-IL, were coated into the capillary inner wall. Compared to anuncoated capillary, thenew systems show good reproducibility and durability. The systems based on the use of MNP--CD or MNP--CD-IL as stationary phases were established for enantioseparation of Dns-modifiedamino acids. Improved resolutions were obtained for both CEC systems. Primary parameters such as running buffer pH value and applied voltage were systematically optimized in order to obtain optimal enantioseparations. Under the optimized conditions, the capillaries exhibited excellent chiral recognition ability for six Dns-amino acids (the DL-forms of alanine, leucine, lsoleucine, valine, methionine, glutamic acid)and provided a promising way for the preparation of chiral column.
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