Journal
MICROCHEMICAL JOURNAL
Volume 145, Issue -, Pages 180-186Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.microc.2018.10.031
Keywords
Deep eutectic solvents; Flavone C-glycosides; Flos Trollii; Extraction; Response surface methodology
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Funding
- National Natural Science Foundation of China [81803697, 81803685]
- Natural Science Foundation of Hebei Province [H2018205185, H2018423032]
- Research Foundation of Hebei Province Education Department [QN2017093]
- Research Foundation of Hebei Provincial Administration of Traditional Chinese Medicine [2018108]
- Science Foundation of Hebei University of Chinese Medicine [BSZ2017003]
- Science Foundation of Hebei Normal University [L2017B11]
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Nowadays, deep eutectic solvents (DESs) are emerging as a new type of green and sustainable solvents for efficient extraction of bioactive compounds from natural products. In the present study, to evaluation of DESs for the extraction of flavone C-glycosides, a total of twelve choline chloride based DESs were tailored for simultaneous extraction three main bioactive flavone C-glycosides (2-O-galactopyranosylorientin, orientin and vitexin) from Flos Trollii. The DES composed of choline chloride and zinc bromide showed the best extraction efficiency for the flavone C-glycosides compared with conventional organic solvents (methanol and 50% methanol). Subsequent, the extraction parameters for the three flavone C-glycosides, including liquid-solid ratios, water content (%) in the selected DESs, and extraction time were optimized using response surface methodology and the optimal extraction condition are liquid-solid ratio, 42 mL/g; water content, 48%; extraction time, 28 min. In addition, the three flavone C-glycosides were recovered from DESs by macroporous resin (D101) with a satisfactory yield between 75.4% and 80.5%. The present research indicated that DESs were efficient and sustainable for extraction main flavone C-glycosides from Flos Trollii and the data acquired in this study could contribute to further DESs application in extraction of bioactive compounds from natural products.
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