Silver nanofibers/ionic liquid nanocomposite based electrochemical sensor for detection of clonazepam via electrochemically amplified detection

In this work, an electrochemical sensing platform based on nanostructured silver fibers (SFs) and Ionic liquid (IL) composite (SFs - IL) was developed for electrochemical sensor. Glassy carbon electrode modified with SFs - IL nanocomposite and used to development of the electrochemical sensor for detection of clonazepam, which increase the reduction peak currents of clonazepam and lowering in the peak potential of clonazepam. The improvement of electrochemical response to clonazepam reduction was found at SFs - IL modified electrode, revealing the synergetic effect of SFs and IL. The properties of catalyst materials were characterized by scanning electron microscope, X-ray diffraction, electrochemical impedance spectroscopy, cyclic voltammetry, differential pulse voltammetry, chronoamperometry and electrochemical impedance spectroscopy. SFs - IL modified electrode offers a wide linear range from 0.1 to 250 mu M with a low detection limit of 66 nM, and acceptable reproducibility and stability. Furthermore, the real sample analysis revealed satisfactory recovery for the detection of clonazepam in pharmaceutical formulation, serum and urine samples.