Journal
MICROBIOLOGY-SGM
Volume 165, Issue 5, Pages 492-499Publisher
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.000760
Keywords
mycobacteria; drug discovery; antibiotics; persistence; non-replicating organisms; tuberculosis
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Funding
- Bill and Melinda Gates Foundation [OPP1024038]
- Bill and Melinda Gates Foundation [OPP1024038] Funding Source: Bill and Melinda Gates Foundation
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Bacterial persisters are a subpopulation of cells that exhibit phenotypic resistance during exposure to a lethal dose of antibiotics. They are difficult to target and thought to contribute to the long treatment duration required for tuberculosis. Understanding the molecular and cellular biology of persisters is critical to finding new tuberculosis drugs that shorten treatment. This review focuses on mycobacterial persisters and describes the challenges they pose in tuberculosis therapy, their characteristics and formation, how persistence leads to resistance, and the current approaches being used to target persisters within mycobacterial drug discovery.
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