Journal
MICROBIAL DRUG RESISTANCE
Volume 25, Issue 6, Pages 925-930Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2018.0383
Keywords
NDM-5; Klebsiella pneumoniae, carbapenem resistance; colistin resistance
Funding
- Lebanese Council for Research
- French Government under the Investissements d'avenir (Investments for the Future) program [10-IAHU-03]
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This study aims to describe the molecular mechanisms of carbapenem and colistin resistance in Klebsiella pneumoniae strains isolated from hospitalized patients in Lebanon. We report in this study the first description of NDM-5 producing carbapenem-resistant K. pneumoniae ST383, as well as the presence of two out of five isolates resistant to colistin due to mutations in the amino acid sequences of proteins (PmrB, PhoQ, and MgrB). Therefore, screening of such isolates may be effective in limiting the spread of these resistant microorganisms in hospitalized patients and within the community.
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