Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 408, Issue 10, Pages 2543-2555Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-016-9356-8
Keywords
Chiral ionic liquids; Capillary electrophoresis; Enantiomeric separation; Synergistic system; Molecular modeling
Funding
- National Natural Science Foundation of China [81373378, 81072610]
- Natural Science Foundation of Jiangsu Province [BK20150697]
- Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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In recent years, chiral ionic liquids (CILs) have attracted more and more attention in the field of enantioseparation. In this study, two novel spirocyclic chiral ionic liquids, 1-butyl-3-methylimidazolium(T-4)-bis[(2S)-2-(hydroxy-kappa O)-3-methylbutanoato-kappa O]borate (BMIm(+)BLHvB(-)) and 1-butyl-3-methylimidazolium (T-4)-bis[(alpha S)-alpha-(hydroxy-kappa O)-4-methylbenzeneacetato-kappa O]borate (BMIm(+)BSMB(-)), were applied for the first time in capillary electrophoresis (CE) to establish synergistic systems for enantiomeric separation. Significantly improved separations of five tested analytes were observed in the CILs synergistic systems based on three beta-cyclodextrin derivatives (CD), compared with conventional single CD separation systems. Several principal parameters such as CILs concentration, cyclodextrin concentration, buffer pH, and applied voltage were systematically investigated with BMIm(+)BLHvB(-)/hydroxypropyl-beta-CD selected as a model system to optimize the enantioseparation. Molecular modeling was applied to further demonstrate the chiral recognition mechanism of the CILs/hydroxypropyl-beta-CD synergistic system, which showed a good agreement with the experimental results.
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