Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 408, Issue 17, Pages 4733-4741Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-016-9562-4
Keywords
SERS; Sequential injection analysis; Aspirin; Vitamin C; In situ silver photoreduction
Funding
- Egyptian government for studies abroad
- Austrian research funding association (FFG) under the scope of the COMET program within the research network Process Analytical Chemistry (PAC) [825340]
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In this contribution, the utility of sequential injection analysis in combination with surface-enhanced Raman spectroscopy (SERS) as a detection technique was investigated for simultaneous determination of aspirin and vitamin C in their pharmaceutical dosage forms and in spiked urine samples. The silver substrate was synthesized in situ by laser-induced photochemical procedure. By focusing the laser on a flow cell at 1 ml/min of continuous flow of 0.5 mM silver nitrate and 5 mM sodium citrate mixture, an active silver spot on the inner wall of the flow cell was prepared in a few seconds. The whole setup is fully computer controlled using ATLAS software to combine the two techniques. The system allows sequential determination of aspirin concentrations ranging from 100 to 500 ng/ml and vitamin C concentrations between 10 and 110 ng/ml with good precision of relative standard deviations (RSDs) of 0.85 and 1.7 %, respectively. A comparison of these results with those of the reported procedures showed excellent results compared with t and F values, indicating good accuracy and precision. The detection limits were 32 and 3 ng/ml for aspirin and vitamin C, respectively.
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