Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 408, Issue 12, Pages 3265-3273Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-016-9395-1
Keywords
MDPV; 3,4-Methylenedioxypyrovalerone; Oral fluid; Nasal fluid; Ionmobility spectrometry
Funding
- Ministerio de Economia y Competitividad [CTQ 2012 38635, CTQ 2014 52841]
- Generalitat Valenciana [PROMETEO-II 2014-077]
- University of Valencia [UV-INV-AE14-268280]
Ask authors/readers for more resources
A fast and sensitive methodology has been developed for the evaluation of the 3,4-methylenedioxypyrovalerone (MDPV) consumed. Based on ion mobility spectrometry (IMS), MDPV was directly determined in nasal fluids with a limit of detection (LOD) in the order of 22 ng mL(-1), which corresponds to an absolute amount of 33 ng of MDPV per swab. MDPV was also determined after liquid-liquid microextraction (LLME) in oral fluids to avoid matrix effects, obtaining a LOD value of 4.4 ng mL(-1) in oral fluid samples. The IMS spectrum for MDPV exhibited a peak with K (0) = 1.210 +/- 0.005 cm(2)V(-1) s(-1) at a drift time of 14.62 ms, the total analysis time being 4.5 min per oral fluid and 1.5 min per nasal fluid sample. Samples must be analyzed within 24 h following collection and dissolution in 2-propanol, based on the complementary stability studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available