Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 408, Issue 27, Pages 7719-7729Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-016-9869-1
Keywords
Graphene oxide nanocomposite; Mirtazapine; Dispersive solid-phase microextraction; Plackett-Burman design; Box-Behnken design; High performance liquid chromatography
Funding
- Ferdowsi University of Mashhad, Mashhad, Iran [3/32789]
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Ultrasonic-assisted magnetic dispersive solid-phase microextraction coupled with high performance liquid chromatography has been developed for extraction and determination of mirtazapine, N-desmethyl mirtazapine, and 8-hydroxy mirtazapine in human urine and water samples. Magnetic graphene oxide-polyaniline nanocomposite (MGOPA) as a novel SPME sorbent was synthesized and used for the microextraction process. The analytical performance of MGOPA was compared with magnetic graphene oxide nanocomposite and indicated that the new sorbent was quite effective for extraction of mirtazapine, N-desmethyl mirtazapine, and 8-hydroxy mirtazapine. A two-stage experimental design approach, Plackett-Burman screening design and Box-Behnken optimization design, was used for screening and optimizing of significant variables in the microextraction process. The practical applicability of the proposed method was assessed by studying the linearity, intra-day and inter-day accuracy, enrichment factor, and precision. This method can be satisfactorily applied to the determination of mirtazapine and its metabolites in human urine and environmental water samples.
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