Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 409, Issue 2, Pages 379-394Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-016-9900-6
Keywords
Brain extracellular matrix; Proteoglycans; Glycosaminoglycans; Perineuronal nets; Schizophrenia; Alzheimer's disease
Funding
- NIH [P41GM104602, R21CA177479, R01MH105608]
- NATIONAL CANCER INSTITUTE [R21CA177479] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR010888] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P41GM104603] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH105608, R01MH086522] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Brain extracellular matrix (ECM) is a highly organized system that consists of collagens, noncollagenous proteins, glycoproteins, hyaluronan, and proteoglycans. Recognized physiological roles of ECM include developmental regulation, tissue homeostasis, cell migration, cell proliferation, cell differentiation, neuronal plasticity, and neurite outgrowth. Aberrant ECM structure is associated with brain neurodegenerative conditions. This review focuses on two neurodegenerative conditions, schizophrenia and Alzheimer's disease, and summarizes recent findings of altered ECM components, including proteoglycans, glycosaminoglycans, proteins, and glycoproteins, and proteins and genes related to other brain components. The scope includes immunohistochemical, genomics, transcriptomics, proteomics, and glycomics studies, and a critical assessment of current state of proteomic studies for neurodegenerative disorders. The intent is to summarize the ECM molecular alterations associated with neurodegenerative pathophysiology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available