Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 101, Issue -, Pages 380-386Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2019.03.075
Keywords
Electrospinning; In-situ deposition; NOCA fibers; Kidney; Fast hemostasis
Categories
Funding
- National Natural Science Foundation of China [51673103]
- Shandong Provincial Natural Science Foundation, China [ZR2017BA013]
- China Postdoctoral Science Foundation [2017M612200]
- Postdoctoral Scientific Research Foundation of Qingdao [2016007]
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An auxiliary electrode electrospinning method is proposed to deposit N-octyl-2-cyanoacrylate (NOCA) medical glue fibrous membrane on kidney for in-situ fast hemostasis. A metal electrode equipped to the spinning needle is used to confine the divergence angle of jet. Compared to the conventional electrospinning method, the fiber deposition area has reduced by 2.5 times, and it can achieve in-situ accurate deposition. Moreover, it reduces both the external dimension and over-reliance on electricity, which is superior to previous air-flow assisted electrospinning method. In addition, in situ accurate deposition of NOCA on the kidney exhibits fast hemostasis within 10 s, confirming that this auxiliary electrode method can be applied in outdoors for fast hemostasis. Further pathological studies indicate that this auxiliary electrode method can reduce the inflammatory response of tissues due to the better accurate deposition. This portable hand-held device with the auxiliary electrode method may have potential application in fast hemostasis for outdoors due to its accurate deposition and portability characteristics.
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