Journal
MARINE DRUGS
Volume 17, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/md17030182
Keywords
Diaporthe phaseolorum; deep-sea derived fungus; chromone-derived polyketides; phaseolorins A-F
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Funding
- Science and Technology Program of Guangzhou, China [201607020018]
- Team Project of the Natural Science Foundation of Guangdong Province [2016A030312014]
- National Natural Science Foundation of China [31272087]
- Guangdong Provincial Innovative Development of Marine Economy Regional Demonstration Projects [GD2012-D01-002]
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Five new chromone-derived polyketides phaseolorins A-F (1-5), together with nine known compounds, were isolated from the deep-sea derived fungus Diaporthe phaseolorum FS431. The structures of new compounds were determined by analysis of their NMR and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectroscopic data. The absolute configurations were confirmed by chemical transformations, extensively experimental electron capture detection (ECD) calculations, or X-ray crystallography. Among them, compound 2 represented the first example for a new family of chromone derivative possessing an unprecedented recombined five-member -lactone ring. Moreover, the new compounds (1-5) were evaluated for in vitro cytotoxic activities against a panel of human cancer cell lines.
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