Journal
MARINE DRUGS
Volume 17, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/md17030176
Keywords
herqueinones; phenalenones; Penicillium sp; marine-derived fungi; adipogenesis; anti-angiogenesis; anti-inflammatory
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Funding
- National Research Foundation (NRF) [2018R1A4A1021703]
- Ministry of Science, ICT, & Future Planning, Korea
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Six new phenalenone derivatives (1-6), along with five known compounds (7-11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.
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