Journal
MARINE DRUGS
Volume 17, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/md17020080
Keywords
quorum sensing; quorum sensing inhibitor; marine microorganism; derivatives
Categories
Funding
- National Natural Science Foundation of China [81773628, 81741165, 41776139]
- National Key R&D Program of China [2017YFE0103100, 2018YFC0311003]
- China Postdoctoral Science Foundation [2017M620254]
- Zhejiang Postdoctoral Science Foundation
- Foundation of Key Laboratory of Marine Ecosystem and Biogeochemistry, SOA [LMEB201501]
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Quorum sensing inhibitors (QSIs) present a promising alternative or potent adjuvants of conventional antibiotics for the treatment of antibiotic-resistant bacterial strains, since they could disrupt bacterial pathogenicity without imposing selective pressure involved in antibacterial treatments. This review covers a series of molecules showing quorum sensing (QS) inhibitory activity that are isolated from marine microorganisms, including bacteria, actinomycetes and fungi, and chemically synthesized based on QSIs derived from marine microorganisms. This is the first comprehensive overview of QSIs derived from marine microorganisms and their synthetic analogues with QS inhibitory activity.
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