Journal
MALARIA JOURNAL
Volume 18, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12936-019-2724-z
Keywords
Malaria; Plasmodium; Mechanism of action; Drug discovery; Drug development
Categories
Funding
- Australian Research Council
- Medicines for Malaria Venture [LP150101226]
- Australian Research Council [LP150101226] Funding Source: Australian Research Council
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Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria prevention and the use of artemisinin-based combination therapy (ACT) for malaria treatment have made a significant impact. Nevertheless, the development of resistance to the past and present anti-malarial drugs highlights the need for continued research to stay one step ahead. New drugs are needed, particularly those with new mechanisms of action. Here the range of anti-malarial medicines developed over the years are reviewed, beginning with the discovery of quinine in the early 1800s, through to modern day ACT and the recently-approved tafenoquine. A number of new potential anti-malarial drugs currently in development are outlined, along with a description of the hit to lead campaign from which it originated. Finally, promising novel mechanisms of action for these and future anti-malarial medicines are outlined.
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