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Urinary biomarkers for lupus nephritis: the role of the vascular cell adhesion molecule-1

Journal

LUPUS
Volume 28, Issue 3, Pages 265-272

Publisher

SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203319826695

Keywords

Lupus nephritis; urinary biomarkers; VCAM-1

Categories

Funding

  1. Research and Events Incentive Fund of the Hospital de Clinicas de Porto Alegre

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Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predict disease activity and renal histology, but also lead to earlier treatment. In previous studies, the soluble vascular cell adhesion molecule-1 measured in urine showed a strong association with the presence of lupus nephritis, with clinical and histological activity indexes of the disease and with more severe renal lesions. This paper reviews the main urinary biomarkers of lupus nephritis that have been studied, with special emphasis on vascular cell adhesion molecule-1 results.

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