Journal
LIFE SCIENCES
Volume 219, Issue -, Pages 100-108Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2019.01.008
Keywords
Maternal high-fat diet; Offspring; Adipose tissue; Inflammation; Immunologic aging; Non-alcoholic fatty liver disease
Funding
- Japan Society for the Promotion of Science KAKENHI [16K16290]
- Grants-in-Aid for Scientific Research [16K16290] Funding Source: KAKEN
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Aim: Maternal obesity and improper nutrition predispose offspring to chronic metabolic diseases. Although the frequency of these diseases increases with aging, the effect of a maternal high-fat diet on aged offspring remains elusive. Main methods: C57BL/6J female mice were fed a high-fat (HF) diet or a control (CON) diet and then mated. All offspring remained with their birth dam until weaning at 3 weeks. After weaning, the offspring from the HF and CON diet-fed dams were given either the HF diet or CON diet, which resulted in four groups: CON/CON, CON/HF, HF/CON, and HF/HF. All mice were immunized with ovalbumin and then sacrificed at 70 weeks. Key findings: The body weights in offspring from dam exposed to a HF diet were significantly higher than those in offspring from dam fed a CON diet in the early stage of life but then became lower in the later stage of life. The serum adiponectin levels were lower in offspring from dam exposed to a HF diet and were correlated with adiposity measured by visceral and subcutaneous fat mass. Non-alcoholic fatty liver disease was much more severe in the livers of offspring from the maternal HF groups. In particular, lobular inflammation and fibrosis were prominent in the HF/HF group. Regarding immunological parameters, senescence-associated T cells were increased, and natural killer T cells were decreased by the effect of both maternal and offspring HF diet. Significance: We have demonstrated that a maternal high-fat diet may accelerate the adipo-immunologic aging process.
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