Related references
Note: Only part of the references are listed.Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS
Y. Mei et al.
LEUKEMIA (2018)
Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients
Jiayi Yu et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)
Sotatercept with long-term extension for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes: a phase 2, dose-ranging trial
Rami Komrokji et al.
LANCET HAEMATOLOGY (2018)
Investigational drugs in phase I and phase II clinical trials for thalassemia
Irene Motta et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2017)
New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration
Svitlana Pasteuning-Vuhman et al.
FASEB JOURNAL (2017)
Luspatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes (PACE-MDS): a multicentre, open-label phase 2 dose-finding study with long-term extension study
Uwe Platzbecker et al.
LANCET ONCOLOGY (2017)
Increasing the effectiveness of hematopoiesis in myelodysplastic syndromes: erythropoiesis-stimulating agents and transforming growth factor-beta superfamily inhibitors
Anna Mies et al.
SEMINARS IN HEMATOLOGY (2017)
Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP
Deepankar Gahloth et al.
STRUCTURE (2017)
Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection
Shomyseh Sanjabi et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)
Phase 1b study of galunisertib in combination with gemcitabine in Japanese patients with metastatic or locally advanced pancreatic cancer
Masafumi Ikeda et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2017)
Stem and progenitor cell alterations in myelodysplastic syndromes
Aditi Shastri et al.
BLOOD (2017)
Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies
Haralambos Raftopoulos et al.
SUPPORTIVE CARE IN CANCER (2016)
TGF-β inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors
Xiaofei Gao et al.
BLOOD (2016)
Physiologic Expression of Sf3b1K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation
Esther A. Obeng et al.
CANCER CELL (2016)
Novel oral transforming growth factor- signaling inhibitor EW-7197 eradicates CML-initiating cells
Kazuhito Naka et al.
CANCER SCIENCE (2016)
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9
Rebekka K. Schneider et al.
NATURE MEDICINE (2016)
Activin Receptor II Ligand Traps and Their Therapeutic Potential in Myelodysplastic Syndromes with Ring Sideroblasts
Anna Mies et al.
CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2016)
Immunoregulation by members of the TGFβ superfamily
WanJun Chen et al.
NATURE REVIEWS IMMUNOLOGY (2016)
Deconstructing the Complexity of TGFβ Signaling in Hematopoietic Stem Cells: Quiescence and Beyond
Ashwini Hinge et al.
CURRENT STEM CELL REPORTS (2016)
Bone morphogenetic protein antagonist gremlin-1 regulates colon cancer progression
George S. Karagiannis et al.
BIOLOGICAL CHEMISTRY (2015)
TGF-β signaling in the control of hematopoietic stem cells
Ulrika Blank et al.
BLOOD (2015)
The TGF-β superfamily in dendritic cell biology
Pascal Seeger et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2015)
Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes
I. Ganan-Gomez et al.
LEUKEMIA (2015)
Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway
Stephan Herbertz et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2015)
RAP-011, an activin receptor ligand trap, increases hemoglobin concentration in hepcidin transgenic mice
Jacqueline M. Langdon et al.
AMERICAN JOURNAL OF HEMATOLOGY (2015)
Myelodysplasia is in the niche: novel concepts and emerging therapies
E. Bulycheva et al.
LEUKEMIA (2015)
Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells
H. Dolatshad et al.
LEUKEMIA (2015)
A phase 1 study of ACE-536, a regulator of erythroid differentiation, in healthy volunteers
Kenneth M. Attie et al.
AMERICAN JOURNAL OF HEMATOLOGY (2014)
Isolation and transcriptome analyses of human erythroid progenitors: BFU-E and CFU-E
Jie Li et al.
BLOOD (2014)
An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin
Soraya Carrancio et al.
BRITISH JOURNAL OF HAEMATOLOGY (2014)
Sotatercept in patients with osteolytic lesions of multiple myeloma
Kudrat M. Abdulkadyrov et al.
BRITISH JOURNAL OF HAEMATOLOGY (2014)
Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling
Janet L. Crane et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells
Meng Zhao et al.
NATURE MEDICINE (2014)
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
Michael Dussiot et al.
NATURE MEDICINE (2014)
Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis
Rajasekhar N. V. S. Suragani et al.
NATURE MEDICINE (2014)
Targeting a new regulator of erythropoiesis to alleviate anemia
Robert F. Paulson
NATURE MEDICINE (2014)
miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling
Tushar D. Bhagat et al.
BLOOD (2013)
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
Francesco S. Loffredo et al.
CELL (2013)
Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes
Jeong-Hwan Yoon et al.
EMBO MOLECULAR MEDICINE (2013)
Stromal cell-mediated inhibition of erythropoiesis can be attenuated by Sotatercept (ACE-011), an activin receptor type II ligand trap
Camelia Iancu-Rubin et al.
EXPERIMENTAL HEMATOLOGY (2013)
Genome-wide mechanisms of Smad binding
M. Morikawa et al.
ONCOGENE (2013)
Beyond TGFβ: roles of other TGFβ superfamily members in cancer
Lalage M. Wakefield et al.
NATURE REVIEWS CANCER (2013)
Dendritic cell lineage commitment is instructed by distinct cytokine signals
Kristin M. Sere et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2012)
Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis
Peter C. Gray et al.
FEBS LETTERS (2012)
TGFβ signalling in context
Joan Massague
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Regulation of TGF-β receptor activity
Fei Huang et al.
CELL AND BIOSCIENCE (2012)
Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase
Li Zhou et al.
CANCER RESEARCH (2011)
Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling
Alan C. Mullen et al.
CELL (2011)
Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
Satoshi Yamazaki et al.
CELL (2011)
Common structural traits for cystine knot domain of the TGFβ superfamily of proteins and three-fingered ectodomain of their cellular receptors
A. Galat
CELLULAR AND MOLECULAR LIFE SCIENCES (2011)
Normal and malignant megakaryopoiesis
Qiang Wen et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2011)
TGF-beta 1-induced PI3K/Akt/NF-kappa B/MMP9 signalling pathway is activated in Philadelphia chromosome-positive chronic myeloid leukaemia hemangioblasts
Xishan Zhu et al.
JOURNAL OF BIOCHEMISTRY (2011)
Latent TGF-β structure and activation
Minlong Shi et al.
NATURE (2011)
A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys
Sutada Lotinun et al.
BONE (2010)
Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1
Grant A. Challen et al.
CELL STEM CELL (2010)
Origin and development of dendritic cells
Kang Liu et al.
IMMUNOLOGICAL REVIEWS (2010)
Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter
Adele Hannigan et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
TGF-β1 Accelerates Dendritic Cell Differentiation from Common Dendritic Cell Progenitors and Directs Subset Specification toward Conventional Dendritic Cells
Piritta Felker et al.
JOURNAL OF IMMUNOLOGY (2010)
Type II Transforming Growth Factor-β Receptor Recycling Is Dependent upon the Clathrin Adaptor Protein Dab2
Sumedha G. Penheiter et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
TGF-β-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
Kazuhito Naka et al.
NATURE (2010)
Regulation of TGF-beta signaling by Smad7
Xiaohua Yan et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2009)
Complex and Context Dependent Regulation of Hematopoiesis by TGF-beta Superfamily Signaling
Sofie Singbrant Soderberg et al.
HEMATOPOIETIC STEM CELLS VII (2009)
TGF-β receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-β
Andres Rojas et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)
Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom
Lukasz Huminiecki et al.
BMC EVOLUTIONARY BIOLOGY (2009)
Nucleocytoplasmic shuttling of Smad proteins
Caroline S. Hill
CELL RESEARCH (2009)
TGF-β Superfamily Signaling in Embryonic Development and Homeostasis
Mary Y. Wu et al.
DEVELOPMENTAL CELL (2009)
Single-Dose, Randomized, Double-Blind, Placebo-Controlled Study of ACE-011 (ActRIIA-IgG1) in Postmenopausal Women
Jon Ruckle et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2009)
Role of transforming growth factor-beta superfamily signaling pathways in human disease
Kelly J. Gordon et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2008)
Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS
Li Zhou et al.
BLOOD (2008)
Identification of distinct inhibin and transforming growth factor β-binding sites on betaglycan -: Functional separation of betaglycan co-receptor actions
Ezra Wiater et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Hematopoiesis controlled by distinct TIF1γ and Smad4 branches of the TGFβ pathway
Wei He et al.
CELL (2006)
The early history of TGF-β, and a brief glimpse of its future
MB Sporn
CYTOKINE & GROWTH FACTOR REVIEWS (2006)
Bcr-Abl activates the AKT/FoxO3 signalling pathway to restrict transforming growth factor-β-mediated cytostatic signals
A Atfi et al.
EMBO REPORTS (2005)
BMP signaling and stem cell regulation
JW Zhang et al.
DEVELOPMENTAL BIOLOGY (2005)
A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-β1 in the development of myelofibrosis
AM Vannucchi et al.
BLOOD (2005)
Cytoplasmic PML function in TGF-β signalling
HK Lin et al.
NATURE (2004)
Loss of Smad3 in acute T-cell lymphoblastic leukemia
LA Wolfraim et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Decrease of Smad4 gene expression in patients with essential thrombocythaemia may cause an escape from suppression of megakaryopoiesis by transforming growth factor-beta 1
H Kuroda et al.
BRITISH JOURNAL OF HAEMATOLOGY (2004)
Transforming growth factor-β signaling in normal and malignant hematopoiesis
SJ Kim et al.
LEUKEMIA (2003)
Mechanisms of TGF-β signaling from cell membrane to the nucleus
YG Shi et al.
CELL (2003)
Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFβ family
W Maguer-Satta et al.
EXPERIMENTAL CELL RESEARCH (2003)
Human T-cell lymphotropic virus oncoprotein Tax represses TGF-β1 signaling in human T cells via c-Jun activation:: a potential mechanism of HTLV-I leukemogenesis
B Arnulf et al.
BLOOD (2002)
Prominent role of TGF-β1 in thrombopoietin-induced myelofibrosis in mice
H Chagraoui et al.
BLOOD (2002)
Inhibition of Smad5 in human hematopoietic progenitors blocks erythroid differentiation induced by BMP4
O Fuchs et al.
BLOOD CELLS MOLECULES AND DISEASES (2002)
The role of activin A in regulation of hemopoiesis
Y Shav-Tal et al.
STEM CELLS (2002)
The TGFβ receptor activation process:: An inhibitor- to substrate-binding switch
M Huse et al.
MOLECULAR CELL (2001)
The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway
BA Hocevar et al.
EMBO JOURNAL (2001)
Inhibition of the transforming growth factor β1 signaling pathway by the AML1/ETO leukemia-associated fusion protein
A Jakubowiak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
How cells read TGF-β signals
J Massagué
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)
Transforming growth factor inhibits erythropoiesis by blocking proliferation and accelerating differentiation of erythroid progenitors
Y Zermati et al.
EXPERIMENTAL HEMATOLOGY (2000)
Smads as transcriptional co-modulators
L Attisano et al.
CURRENT OPINION IN CELL BIOLOGY (2000)