Journal
JOURNAL OF VIROLOGY
Volume 93, Issue 8, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02299-18
Keywords
influenza A virus; RIG-I; defective interfering RNA; innate immunity; panhandle
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Public Health Agency of Canada (PHAC)
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Innate immune sensing of influenza A virus (IAV) requires retinoic acid-inducible gene I (RIG-I), a fundamental cytoplasmic RNA sensor. How RIG-I's cytoplasmic localization reconciles with the nuclear replication nature of IAV is poorly understood. Recent findings provide advanced insights into the spatiotemporal RIG-I sensing of IAV and highlight the contribution of various RNA ligands to RIG-I activation. Understanding a compartment-specific RIG-I-sensing paradigm would facilitate the identification of the full spectrum of physiological RIG-I ligands produced during IAV infection.
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