Journal
ANALYST
Volume 141, Issue 8, Pages 2595-2599Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6an00273k
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A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 mu M up to 2 mM.
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