Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 397, Issue -, Pages 34-41Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2018.12.022
Keywords
Intracerebral hemorrhage; Leukoaraiosis; Prognosis
Categories
Funding
- Outstanding Subject Development 135 Project of West China Hospital, Sichuan University [ZY2016102]
Ask authors/readers for more resources
Background: Patients with intracerebral hemorrhage (ICH) have high disability and mortality. Leukoaraiosis refers to the diffuse abnormalities of white matter on neuroimaging, which has been suggested to be with poor outcome in patients with ICH. This meta-analysis was performed to summarize the current evidence on the prognostic significance of leukoaraiosis in ICH patients. Methods: Databases were searched for published studies about leukoaraiosis and prognosis in patients with ICH. Data from eligible studies were extracted. Odds ratios (ORs) and their 95% confidence intervals (CIs) from each study were combined with DerSimonian Laird method and random effect model for quantitative analysis. Begg's funnel plot was adopted to assess the publication bias. Results: A total of nine studies with 4948 patients were finally included in this meta-analysis. Six studies reported functional outcome, two studies reported mortality, and another study reported both functional outcome and mortality. The meta-analysis showed that leukoaraiosis was significantly associated with worse functional outcome in patients with ICH (OR = 1.40, 95%CI 1.17-1.68, P < .001). In addition, leukoaraiosis was also significantly associated with higher mortality in patients with ICH (OR = 1.59, 95%Cl 1.21-2.08, P = .001). Conclusions: Leukoaraiosis is significantly associated with both worse functional outcome and higher mortality in patients with ICH. Leukoaraiosis can be a useful imaging marker for predicting outcome in patients with ICH.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available