Journal
ANALYST
Volume 141, Issue 18, Pages 5358-5365Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6an01076h
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Funding
- NIH Director's New Innovator Award Program, part of the NIH Roadmap for Medical Research [1-DP2-OD002190-01]
- National Science Foundation [CHE 12-14081]
- National Science Foundation Graduate Research Fellowship
- Division of Analytical Chemistry Summer Graduate Research Fellowship - Society for Analytical Chemists of Pittsburgh
- American Heart Association
- REU program at the University of Illinois Department of Chemistry - 3 M
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1214081] Funding Source: National Science Foundation
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The analysis of disease-specific biomarker panels holds promise for the early detection of a range of diseases, including cancer. Blood-based biomarkers, in particular, are attractive targets for minimally-invasive disease diagnosis. Specifically, a panel of organ-specific biomarkers could find utility as a general disease surveillance tool enabling earlier detection or prognostic monitoring. Using arrays of chip-integrated silicon photonic sensors, we describe the simultaneous detection of eight cancer biomarkers in serum in a relatively rapid (1 hour) and fully automated antibody-based sandwich assay. Biomarkers were chosen for their applicability to a range of organ-specific cancers, including disease of the pancreas, liver, ovary, breast, lung, colorectum, and prostate. Importantly, we demonstrate that selected patient samples reveal biomarker fingerprints that may be useful for a personalized cancer diagnosis. More generally, we show that the silicon photonic technology is capable of measuring multiplexed panels of protein biomarkers that may have broad utility in clinical diagnostics.
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