Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 13, Pages 5125-5129Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b00837
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Funding
- Ministerio de Economia y Competitividad [FJCI-2017-33168]
- Juan de la Cierva-Incorporacion fellowships [IJCI-2015-23210]
- Ministerio de Educacion, Cultura y Deporte [FPU17/00711]
- Spanish Government [SAF2016-76689-R, CTQ2016-81797-REDC]
- Conselleria de Cultura, Educacion e Ordenacion Universitaria [2015-CP082, ED431C 2017/19]
- Centro Singular de Investigacion de Galicia accreditation 2016-2019 [ED431G/09]
- European Union (European Regional Development Fund-ERDF)
- European Research Council [340055]
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Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the in cellulo generation of fluorescent and bioactive probes. Overall, our research reveals a novel metal-based tool for cellular intervention, and comes to further demonstrate the compatibility of organometallic mechanisms with the complex environment of cells.
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