Journal
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume 57, Issue 18, Pages 1947-1955Publisher
WILEY
DOI: 10.1002/pola.29330
Keywords
catalysis; discrete oligomers; flow reaction; oligomers; oxygen tolerance; PET-RAFT polymerization; reversible addition-fragmentation chain transfer (RAFT); single unit monomer insertion
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Funding
- Australian Research Council (ARC) [FT160100095]
- Australian Government
- Australian Research Council [FT160100095] Funding Source: Australian Research Council
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As one of the emerging techniques for preparing discrete oligomers, the photo-RAFT single unit monomer insertion (SUMI) process has shown its uniqueness and superiority in the control of both monomer sequence and stereochemistry. However, current precision polymer synthesis techniques are still burdened by the scalability challenges, such as low reaction yields, small product quantities, and long production times. Herein, we successfully established a practical protocol to address scalability problems in the photo-RAFT SUMI processes. A series of discrete oligomers containing up to five monomer units were synthesized in batch and flow reactors by sequential and alternating SUMI of two monomers into a trithiocarbonate RAFT agent under mild reaction conditions and purified by automated flash chromatography. This protocol offers the process with large quantity (grams scale), excellent isolated yields (82%-95% for each step and 59% for five iterations), and short production time (several days for a pentamer). (c) 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1947-1955
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