Journal
JOURNAL OF PHYSICS D-APPLIED PHYSICS
Volume 52, Issue 19, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6463/ab08c1
Keywords
gold-supported graphene; SPR; D-POF; dopamine; conformational transformation
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Funding
- National Natural Science Foundation of China [11804200, 11774208, 11474187, 11674199, 11604040]
- Shandong Province Natural Science Foundation [ZR2017BA004, ZR2016AM19]
- Shandong Province Higher Educational Science and Technology Program [J18KZ011]
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An Au film/graphene D-shaped plastic optical fiber (D-POF) functionalized with dopamine-binding aptamer (DBA) was proposed to achieve a sensitive and specific detection of the small molecule dopamine. The surface plasmon resonance sensor combines the virtues of a D-shaped fiber, the transfer of graphene via gold film, and the amplification of the refractive index with the conformational transformation of DBA. The sensitivity of the Au film/graphene D-POF sensor (1539 mm/RIU) is higher than that without graphene in ethanol solution. The dopamine concentrations of 10(-10) M to 10(-6) M were measured. And the decoration of DBA onto graphene for dopamine detection with a good linearity was verified in experiments. The proposed sensor possesses high sensitivity and specificity, which will provide good application prospects for the development of biosensing in disease treatment.
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