Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 9, Pages 5005-5020Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02971
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Funding
- Science and Engineering Research Board (SERB), New Delhi
- NIT Manipur [ECR/2016/000337]
- Ministry of Human Resource and Development (MHRD), New Delhi
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The Pd-catalyzed decarboxylation and dual C(sp(3))-H bond functionalization approaches have been described for the preparation of symmetrical and unsym-metrical 2,4-diarylpyridines. The developed transformations were realized using nonactivated aromatic ketones and amino acids as C-N sources. The efficacy of the catalyst and reagent combination drives the transformation toward the formation of desired products with high yields and selectivity. The described reaction conditions have seduced the self-reaction of phenylalanine via [2 + 2 + 2] cycloaddition and minimized the formation of 3,5-phenylpyridine as a side product, whereas using glycine as a C-N source, the corresponding 2,6-diarylpyridines were formed as minor products.
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