Visible-Light-Induced Regioselective Cross-Dehydrogenative Coupling of 2H-Indazoles with Ethers

A visible-light-promoted regioselective C(sp(2))-H/C(sp(3))-H cross-dehydrogenative coupling between 2H-indazoles and ethers has been achieved using a catalytic amount of rose bengal as an organophotoredox-catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant at ambient temperature under aerobic conditions. A variety of C-3 oxyalkylated 2H-indazoles have been synthesized in moderate to good yields. Mechanistic studies suggest a radical pathway of the present reaction.