4.7 Article

Pd/Cu Cocatalyzed Oxidative Tandem C-H Aminocarbonylation and Dehydrogenation of Tryptamines: Synthesis of Carbolinones

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 6, Pages 3357-3369

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b03266

Keywords

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Funding

  1. NNSFC [21572238, 21633013, 21772208, 21702212]
  2. NSFC of Jiangsu Province [BK20161260]
  3. Hundred Talented Program of the Chinese Academy of Sciences

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The Pd/Cu cocatalyzed oxidative tandem C-H aminocarbonylation and dehydrogenation was developed, affording carbolinones with molecular oxygen as the terminal oxidant. Natural product strychnocarpine and its derivatives were prepared conveniently using this strategy.

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